ea0094p352 | Metabolism, Obesity and Diabetes | SFEBES2023
Ojeda Laura
, Onishi Ami
, Junior Jair
, Von Kriegsheim Alex
, Morton Nicholas
, Al-Mrabeh Ahmad
Background and Aims: Obesity is a major risk factor for type 2 diabetes (T2D). Remission of diabetes can be achieved by dietary weight loss although the underlying molecular mechanism(s) are unknown. These beneficial effects could be related to decreasing hepatic fat delivery to the pancreas and eventually restoring β-cell function. We hypothesised that hepatic de novo lipogenesis (DNL) is the primary driver of pancreas lipotoxicity and the pr...